城西大学機関リポジトリJURA人工汗を用いた放出試験による先発パップ剤と後発パップ剤の比較

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人工汗を用いた放出試験による先発パップ剤と後発パップ剤の比較

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ID	JOS-jjphcs.30.723
タイトル：カナ	ジンコウアセオモチイタホウシュツシケンニヨルセンパツパップザイトコウハツパップザイノヒカク
別タイトル	Comparison of Drug Release Characteristics between Brand Name and Generic Cataplasms Using Artificial Sweat as Testing Medium
著者：名前	平舩, 寛彦/島村, 剛史/上田, 秀雄/沼尻, 幸彦/小林, 大介/森本, 雍憲
著者：別形式	Tairabune, Tomohiko / Shimamura, Takeshi / Ueda, Hideo / Numajiri, Sachihiko / Kobayashi, Daisuke / Morimoto, Yasunori
著者：カナ	タイラブネ, トモヒコ/シマムラ, タケシ/ウエダ, ヒデオ/ヌマジリ, サチヒコ/コバヤシ, ダイスケ/モリモト, ヤスノリ
著者：所属	城西大学薬学部病院薬剤学講座 / 城西大学薬学部病院薬剤学講座 / 城西大学薬学部病院薬剤学講座 / 城西大学薬学部病院薬剤学講座 / 城西大学薬学部病院薬剤学講座 / 城西大学薬学部病院薬剤学講座
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Department of Hospital Pharmacy
著者版フラグ	publisher
出版地	東京
出版者	日本医療薬学会
出版者：カナ	ニホンイリョウヤクガクカイ
出版者：別名	Japanese Society of Pharmaceutical health Care and Sciences
NCID	AA11527197
冊子ISSN	1346342X
電子ISSN	18821499
掲載誌名	医療薬学
掲載誌名：翻訳	Japanese Journal of Pharmaceutical Health Care and Sciences
巻	30
号	11
刊行年月	2004
開始ページ	723
終了ページ	729
コンテンツ作成日	2004-09-09
コンテンツ登録日	2014-02-20
識別番号：DOI	info:doi/10.5649/jjphcs.30.723
識別番号：DOI（リンク）	http://dx.doi.org/10.5649/jjphcs.30.723
識別番号：その他	JOI:JST.Journalarchive/jjphcs2001/30.723
抄録	The drug release and swelling characteristics of cataplasms may be evaluated using artificial sweat. In our study, these characteristics were compared among brand name and generic cataplasms containing nonsteroidal anti-inflammatory drugs (NSAIDs ; indomethacin (IM) (8 products), ketoprofen (KP) (7 products) and flurbiprofen (FP) (4 products)) using artificial sweat and the apparatus described in JP 14 Dissolution Test Method 2. For cataplasms containing IM and FP, the degree of swelling of generic products was less than that of brand name products but there was no significant difference in release rate. On the other hand, for KP-containing cataplasms, disintegration of the base material was observed for three of the four generic products tested, and all four had higher release rates than the brand name products. Thus, the drug release testing method used in the present study showed that the release and swelling characteristics differed between brand name and generic cataplasms and we felt that it was a useful way of evaluating their quality.
キーワード	generic/release test/cataplasm/artificial sweat/swelling
言語	jpn
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright ? Japanese Society of Pharmaceutical Health Care and Sciences
このアイテムを表示する：本文(pdf)	( 1.0MB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-jjphcs.30.723

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